have not had any treatment for your medulloblastoma apart from surgery or 1 cycle of carboplatin and etoposide if you needed to start treatment straightaway.have a high risk medulloblastoma, your doctor will be able to tell you if yours is high risk.
Qarc medulloblastoma trial#
You may be able to join this trial if all of the following apply. Talk to your doctor or the trial team if you are unsure about any of these. Treatment of adults with medulloblastoma is largely based on data regarding the treatment of children.The following bullet points are a summary of the entry conditions for this trial. Concurrent chemotherapy is sometimes used as well, but this remains controversial with the biggest concern of depressed blood counts given the amount of bone marrow irradiated.Ĭraniospinal irradiation remains the cornerstone of therapy followed by adjuvant chemotherapy. Overall, given the large volume irradiated, more advanced techniques such as proton therapy, tomotherapy, or IMRT have been utilized to decrease acute and late effects of treatment. Given this, specific contouring guidelines are important to include the cribriform plate and other foramina that contain cerebrospinal fluid (CSF) with more targeted plans. In the 3D conformal era for craniospinal irradiation, these areas were automatically included in the fields.
This chapter describes specific directions for inclusion of all areas of CSF and planning pearls. KeywordsĪjithkumar T et al (2018) SIOPE-brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy. Radiother Oncol 128(2):192–197Ĭao F, Ramaseshan R, Corns R, Harrop S, Nuraney N, Steiner P, Aldridge S, Liu M, Carolan H, Agranovich A, Karvat A (2012) A three-isocenter jagged-junction IMRT approach for craniospinal irradiation without beam edge matching for field junctions. Lin H, Ding X, Kirk M, Liu H, Zhai H, Hill-Kayser CE, Lustig RA, Tochner Z, Both S, McDonough J (2014) Supine craniospinal irradiation using a proton pencil beam scanning technique without match line changes for field junctions. Paulino AC, Lobo M, Teh BS, Okcu MF, South M, Butler EB, Su J, Chintagumpala M (2010) Ototoxicity after intensity-modulated radiation therapy and cisplatin-based chemotherapy in children with medulloblastoma. Haas-Kogan D et al (2013) National Cancer Institute Workshop on proton therapy for children: considerations regarding brainstem injury. IJROBP 101(1):153–168īrown AP et al (2013) Proton beam craniospinal irradiation reduces acute toxicity for adults with medulloblastoma. Int J Radiat Oncol Biol Phys 86(2):277–284įranceschi E, Hofer S, Brandes AA et al (2019) EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma. Merchant TE et al (2008) Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma. Michalski JM et al (2016) Results of COG ACNS0331: a phase III trial of involved-field radiotherapy (IFRT) and low dose craniospinal irradiation (LD-CSI) with chemotherapy in average-risk medulloblastoma: a report from the Children’s Oncology Group.Bernadine Donahue 1*, Mary A. Iandoli 3, Thomas FitzGerald 3, Emiko Holmes 4, Mehmet Kocak 5,6, James M.
1New York University School of Medicine, New York, NY, USA.3Quality Assurance Review Center, Lincoln, RI, USA.4Children’s Oncology Group, Arcadia, CA, USA.Jude Children’s Research Hospital, Memphis, TN, USA.6University of Tennessee Health Science Center, Memphis, TN, USA.7Children’s National Medical Center, Washington, DC, USA.Purpose: Associations of radiation therapy (RT) deviations and outcomes in medulloblastoma have not been defined well, particularly in the era of reduced-dose craniospinal irradiation and chemotherapy. The aim of this study is to evaluate the quality of RT on Children’s Cancer Group/Pediatric Oncology Group 9961 and analyze associations of RT deviations with outcome. Materials and Methods: Major volume deviations were assessed based on the distance from specified anatomical region to field edge.
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